Site-specific nutrient management (SSNM) may potentially improve production efficiency and reduce negative impacts of agriculture on the environment. However, research has shown mixed results of this technology and its adoption is slower than expected. This presentation outlines a framework for variable rate N application at field scale, including yield monitor data processing, soil mapping with secondary information, yield goal delineation, and variable rate map developments for N and seed. Results of a two-year study with irrigated corn will be presented. The opportunity and challenges of the precision agriculture approach and its application in manure management are also discussed.