Sesbania drummondii, which accumulates high lead concentrations, was grown in increasing concentrations of copper sulfate both hydroponically (0-300 mg/L) and in soil (500 mg/L, 1000 mg/L, 500 mg/L + EDTA, 1000 mg/L + EDTA) under greenhouse conditions. Growth of plants was inhibited at levels over 200 mg CuSO4/L in the hydroponic condition but plants grown in soil containing different concentrations of copper and EDTA accumulated biomass significantly. Plants grown on Cu and EDTA registered a better growth than plants grown on Cu only. Plants were further evaluated for photosynthetic efficiency (Fv/Fm) and photosynthetic integrity (Fv/Fo). Different treatments of copper and EDTA had demonstrated no adverse effect on Fv/Fm and Fv/Fo in both conditions. Accumulations of Cu in plant root and shoot will be measured and the sites of Cu deposits will be demonstrated using Scanning Electron Microscopy and Energy Dispersive X-ray Spectroscopy. This study indicates the potential of Sesbania drummondii for its use in phytoextraction of Cu.