Phenylketonuria (PKU) is an inherited genetic disorder in which individuals cannot break down the amino acid phenylalanine.  A build-up of phenylalanine in the bloodstream results in seizures, brain damage, and mental disorder. Individuals suffering from this disease must maintain a strict life-long diet low in PHE. This low protein diet is supplemented by a heat-liable, malodorous, distasteful phenylalanine-free crystalline amino acids.  The long-term goal of our project is to provide PKU patients with a more nutritious, palatable source of dietary protein. Our strategy is to produce a phenylalanine-free protein in transgenic soybean and wheat as a value-added (nutraceutical) trait, which then can be separated from the native proteins and used as a protein supplement. To test the feasibility of our project we have transformed both soybean and wheat with both the native 27kD gamma zein gene and a synthetic version lacking phenylalanine codons. We will report our ongoing efforts on this project including our molecular, protein, and amino acid analyses of our transgenic plants as well as efforts on protein extraction and purification.