Invasive weedy plants are a widespread problem throughout the United States. Their growth is often widely dispersed, with little scientific ability to predict why they occur in a given location. In addition, historical human activities such as urbanization, agriculture, and forestry have a marked effect on the distribution and spread of invasives. This project will quantify relationships of weed distribution and spread with land use, then use that information directly in educating agriculture stakeholders, natural resources managers, and other interested parties on potential human-induced opportunities for invasive species spread. The Invasive Plant Atlas of the Mid-South (IPAMS) will provide information on the biology, distribution, and best management practices for forty weedy plant species in the targeted states of Alabama, Arkansas, Louisiana, Mississippi, and Tennessee. Outreach and extension activities include developing training programs for volunteers and citizen scientists to identify and report invasive species using IPAMS, developing an efficient Early Detection and Rapid Response (EDRR) system for invasive plants, developing best management practices workshops, and developing an online mapping system. Research activities include conducting systematic regional vegetation surveys to assess the distribution of key invasive plants, developing models for predicting the occurrence of target species based on land use and cover, and evaluating the relative effectiveness of professional versus volunteer surveys. We are coordinating our activities with the state and regional Exotic Pest Plant Councils (EPPCs) and proposed Cooperative Weed Management Areas (CWMAs), and enlisting the assistance of state Extension Service and Master Gardener organizations.