Potato (Solanum tuberosum L.) production requires high P application with potential negative environmental or nutritional consequences. Impacts of high available P on yield and plant nutrition of species in potato cropping rotations are inadequately understood. Antagonistic interactions with cationic micronutrients such as Zn and Mn are plausible explanations.  Three hydroponic experiments were conducted with Russet Burbank potato to elucidate P and Zn relationships and associated interactions with other nutrients.  In the first experiment, P solution concentration was constant at 256 µM while Zn concentration varied: 0.05, 2, 6, 18, 54, 162 and 456 µM Zn. In the second, Zn solution concentration was constant at 6 µM while P concentration varied:  32, 64, 128, 264, 512, 1024 and 2048 µM P.  In the third, both P and Zn concentrations varied: 32, 128 and 1024 µM P and 0.1, 54 and 486 µM Zn. A direct impact of increasing solution Zn concentration on P uptake in potato was clearly observed. While Zn content increased in all plant parts as solution Zn increased, P concentration declined in both top leaves and middle leaves/stems with a concomitant increase of P in roots. This suggests a P/Zn complex formation in roots preventing movement of P to the tops of plants under high Zn.  This was confirmed when both P and Zn varied (third experiment). Contrary to expectations, a direct impact of increased solution P on Zn uptake or distribution in potato was not observed except at 486 µM Zn in the third experiment. Increased solution P resulted in accumulation of Mn in potato roots which may indirectly impact Zn nutrition in potato.  Although high P levels in potato did not directly reduce Zn content or cause Zn deficiency, high P may reduce the activity of Zn by interacting with other micronutrients such as Mn.