The sessile nature of plants dictates they must rapidly adapt to many abiotic and biotic factors that impact overall plant agronomics and yield. With respect to corn, drought and heat are two major environmental stresses affecting crop yields across the US corn belt and in the majority of corn growing areas of the world. As water becomes more limiting, a drought tolerance trait will increase in both it's impact and value. Through germplasm development and a robust drought screening program, we have identified key inbred and hybrids that deliver enhanced performance under significant water stress conditions in the field. We have leveraged these inbred lines and hybrids in combination with our microarray analysis capabilities to identify a small set of genes that appear to contribute to the stress tolerant phenotype observed in the identified germplasm. Additionally, transgenic events in corn expressing stability variants of ADPglucose pyrophosphorylase that appear to stabilize seed fill under high temperature field conditions have been developed. An overview of our integrated stress tolerance program will be presented.