Land degradation, in particular, soil erosion is either directly or indirectly caused by the different factors of nature, human beings and social economy. Po-yang Lake is one of the largest freshwater lakes in China. Since 1950s, due to population increase, food and fibre requirements and land policy, the land degradation has become more and more serious within Po-yang Lake basin. At present, the degraded land is about 20% of whole 533180hm2 Po-yang Lake basin, The results of RS and GIS researches have shown that landform, soil type, vegetation, precipitation, water quality, land reclamation, cultivation, town development, population increase, life style, and land management policy all have close relations with land degradation. Of these factors, annual precipitation about 1610mm, dense population (each person having only 0.05hm2), expansion of cities and towns and poverty (family annual income only1200-2400 US$ ) are mostly contributed to land degradation. One of the main approaches to prevent the land from degradation may thus be to establish a new relationship among human beings, land and water. Considering land readjustment, ecology rehabilitation, rural ecology construction, and land policy, we put forward a mode for preventing land degradation in this region. The mode is as follows: (1) pay attention to the relations among human beings, land and water, (2) strengthen land readjustment and reduce soil erosion, (3) develop ecology rehabilitation and perfect the construction of nature protection region,(4) build ecological villages and change land use opinion. Key words: Po-yang Lake; land use; land degradation; land readjustment. Biography: Hai-sheng Cai, Ph.D. candidate, mainly engaged in agriculture information technology. Corresponding author at email: zhudehai@263.net.cn