The Effects of Canola Oil and Coconut Oil on Streptozotocin Induced Diabetic Rats.
Farzad Deyhim, Choi Har Kwan, and Jamie C. Laurenz. Texas A&M Univ Kingsville, Dept of Human Sciences, Kingsville, TX 78363
Obesity and increased fat intake are linked to type II diabetes. The objective of the present study was to evaluate the effect of diets containing either canola oil or coconut oil on body weight, food intake, water consumption, blood glucose, and glucose or palmitate uptake in the sham group and streptozotocin induced diabetic rats. Eighty Sprague-Dawley female rats were equally divided among four groups and were fed diets containing either 15% or 47% canola oil or coconut oil. One-half of the rats received an intraperitoneal injection with streptozotocin (STZ) at a rate of 15 mg/kg body weight and the remainder were injected with equal volume of citrate buffer. The dietary treatments for the eight-weeks duration of the study were: 1. Canola oil (15%); 2. Canola oil (15%) + STZ; 3. Coconut oil (15%); 4. Coconut oil (15%) + STZ; 5. Coconut oil (47%); 6. Coconut oil (47%) + STZ; 7. Canola oil (47%); 8. Canola oil (47%) + STZ. Diets were isocaloric and isonitrogenous. All rats were pair-fed to the mean food intake of rats eating 15% canola oil. The initial weight was similar across treatments. Streptozotocin significantly (P<0.05) increased water consumption, and significantly depressed (P<0.05) body weight, feed intake, glucose uptake and palmitate uptake, while increased (P<0.05) blood glucose level. Eating diets containing either canola oil or coconut oil did not affect blood glucose, food consumption, water intake, or body weight. Eating diets containing canola oil significantly (P<0.05) increased glucose and palmitate uptake by muscle cells. The effects were pronounced in rats eating a diet containing 47% canola oil compare to a diet containing 15% canola oil. In conclusion, canola oil increases glucose and palmitate uptake.