Forage/sweet sorghum is a potential crop for producing ethanol throughout the country. However, management practices under different environments have not been determined for forage/sweet sorghum to optimize biomass production and water use efficiency. Crop simulation models, such as EPIC, can be used to calculate long-term production and water use efficiency under a range of environments at many locations. EPIC was calibrated using available measurements collected in 2006 and other years from forage sorghum (first and ratoon crop) in south-central Texas and the Texas panhandle under varying irrigation and nutrient applications. Using calibrated EPIC, long-term simulations will then help one to determine practices to optimize biomass production and water use efficiency for these and other regions of the state. These practices will be compared to practices used on conventional sorghum and corn systems.