The research was conducted at the farm “La Cabaña”, Pluma Hidalgo, Oaxaca, Mexico with total area of 700 ha, about two selected places profile 1 (Chromic Alisol) at 755 m and the profile 2 Fluvic Phaeozem) at 702 m above sea level. Inside toposequence with colluvium accumulation at the shoulder of the slope; fine sorted material containing several buried soils forms a convex slope instead of a concave footslope in the lower part of the toposequence; the profile 2 form part of lower part a sediment discontinuity and the profile 1 is a accumulation zone buried by landslides mustly seismically induced. In the area there are coffee plantation Coffea arabica var. tipica L) and abundant natural plant species as Brosimum alicastrum, Enterolobium cyclocarpus, Pterocarpus acupilcensis, Bursera simaruba, Caesalpinia coriacea, Ceiba pentandra, Cordia aliodora and Ficus sp. In the area studied there are complex relief and sediments of where result an high diversity of soils and the period of instability can be ascribed to various reasons seismically induced, mass movement, tree fall due to hurricanes or forest fires (Krasilnikov et al.2005) In the region was take 5 samples in one area of 25 x 25 m near at profiles and were made 3 replications for determination (phosphomonoesterase, glucosydase, urease, dehydrogenase, microbiological carbon and nitrogen and respiration) (Nannipieri et al., 2001). With the results was made a probe of Tuckey and ANOVA . The results show bigger values in the area of the profile 2 Fluvic Phaeozem per urease (30.82 b±2.5), phosphomonoesterase (39.77b±7.4), dehydrogenase (0.10b±.01), glucosidase (0.91b±.03), carbon( 33.14b±.5.4) and nitrogen (1.56b±.01) microbial and respiration (26.07b±.3.5) this was attributed at the accumulation of sediments and to the bigger quantity and diversity of mesofauna (worms, larvae, insects). This involve one bigger biochemistry activity, biochemistry transformation for accumulation of carbon (31.4 g kg-1). In the area of the Chromic Alisol there was smaller activity for the content of carbon 16.8 g kg-1, for this were considered indicatives of different edaphic and geomorphological characteristics the values at biological and enzymatic activity in the soils of this toposequence from Oaxaca.