Simulation models are becoming of interest as a decision support system for management of crop water use and assessment of production. EPIC was used to compare measured crop evapotranspiration (ET_c) with two methods of estimating ET_c and to evaluate the possibility of using it as a decision support tool for irrigation management of crops. We measured actual ET_c using a weighing lysimeter, soil water with a neutron probe, and crop yields by field sampling. The measured variables were compared with simulated variables using EPIC (erosion productivity impact calculator). Simulated ET_c agreed with the lysimeter, in general, but some simulated ET_c was biased compared with measured ET_c. Simulated soil water, generally, matched with the measured soil water. Furthermore, EPIC was used to simulate yield differences at various irrigation regimes and management strategies. The effectiveness of using EPIC for irrigation scheduling will be discussed in comparison with using reference ET with growth stage specific crop coefficients. The feasibility of using the EPIC model as a decision support tool for real-time management of irrigated crops will be discussed.